The Center for Teaching and Learning is supervised by the Vice Rector of Administrative, Academic and Student Affairs, and is directed by the Center Coordinator. It may be supported by members of the faculty registered in the Register of Collaborators, which is created for this purpose under the responsibility of the Center Coordinator.

The Coordinator is appointed by the Senate for a three-year term upon recommendation of the Senate Committee for Undergraduate Studies and may be the Vice Chair of the Senate Committee for Undergraduate Studies or another member of this committee or a member of the institution’s faculty in general.

The Vice Rector of Administrative, Academic and Student Affairs has the following responsibilities:

• Ensures the implementation of NTUA policy in matters of teaching and learning.
• Decides on all issues concerning the administration and operation of the Center.
• Regulates matters of operation and use of the facilities and equipment.
• Manages and exploits the research results from its activities.
• Decides on the allocation of the Center’s resources and drafts its corresponding budget.
• Takes any other relevant decision for actions related to fulfilling its objectives, in accordance with the provisions of this internal regulation.

The Coordinator of the Center for Teaching and Learning has the following responsibilities:

• Collaborates with the Vice Rector of Administrative, Academic and Student Affairs to promote the objectives and goals of the Center.
• Proposes to the Vice Rector of Administrative, Academic and Student Affairs the annual program of activities of the Center, the annual budget of its activities, as well as the initiatives, actions, and collaborations with external organizations concerning the operation of the Center.
• Collaborates with the Deans and Schools of the University to support the implementation of the educational programs of the Center.
• Collaborates with members of the teaching staff, such as faculty members, adjunct professors, laboratory teaching staff, and other categories of educators at the University, to develop supportive actions aimed at improving teaching and learning at the University.
• Supervises and oversees the operation and evaluation of all kinds of activities developed by the Center.
• Organizes learning circles, training activities, seminars, etc.
• Gathers and/or designs research material.
• Ensures the creation of a repository of educational and research material (in print or electronic form), as well as best practices.
• Collaborates with other similar structures of domestic and foreign universities and develops common actions and synergies.
• Organizes a Registry of collaborating members, either academic personnel or external experts, on teaching and learning matters, in order to support specific and/or specialized actions of the Center.
• Represents the Center within and outside the Institution.
• Coordinates research and funding programs of the Center.
• Is responsible for the financial management of the Center, signs contracts for personnel, supplies, and services that the Center enters into for its general and specific needs, as well as corresponding payment orders.
• Proposes to the Research Committee of the Rectorate the signing of contracts for personnel, supplies, and services that the Center enters into for educational and other functional needs.
• Co-signs contracts for personnel, supplies, and services that the Center enters into for its general needs with the President of the Institution’s Rectorate when he is the scientific supervisor of the projects.
• Forms committees to study or handle specific issues falling within the responsibilities of the Center.
• Drafts an annual report of the Center’s work, which is submitted to the Vice Rector of Administrative, Academic and Student Affairs, as well as to the Center’s Director.
• Is responsible for keeping a record of the actions of the Center and the ability to access them, in accordance with legislative provisions for the protection of personal data. 
• Takes any other relevant initiative in cooperation with the Vice Rector of Administrative, Academic and Student Affairs for actions related to fulfilling the mission of the Center, as defined in its internal operating regulations.

The Center may be assisted in its educational function (support for individual learning circles and its overall actions) by members of the Registry of Collaborators of the NTUA or by the Registry of Collaborators of other tertiary education institutions, institutes, domestic or foreign organizations that include members of teaching and research staff and external experts in the field of teaching and learning.